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In the last decades the keyword non-alcoholic fatty liver disease (NAFLD) was increasingly evoked in research frameworks and in clinical practice. NAFLD is an umbrella term that includes different entities, in particular the simple hepatic fat accumulation, non-alcoholic steatohepatitis characterized by steatosis with necroinflammation, fibrosis and finally cirrhosis and its complications. Globally, the NAFLD prevalence among liver diseases and in general population, is recently rising along with its associated conditions, as obesity, insulin resistance, metabolic syndrome and diabetes. This increment is related to dietary habits and the increase of sedentary lifestyle. Its diffusion seems to be pandemic, given that it is beginning to affect also the populations in the developing world and rural areas, due to the spread of Western lifestyle. Even if the real rate of worldwide incidence of NAFLD are not known, is estimated that its prevalence in general population has reached 20-30% in Western Countries and 5-18% in Asia and it is increasing over time. Currently, NAFLD pathogenesis can be explained by a “multiple hit” hypothesis, that considers multiple factors acting together on genetically predisposed subjects, to induce NAFLD development and progression.

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2017-12-13   |   372 visitas   |   Evalua este artículo 0 valoraciones

Vol. 16 Núm.6. Noviembre-Diciembre 2017 Pags. 826-827 Ann Hepatol 2017; 16(6)