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Pérez Lohman Christian, Kerik  Nora E, Díaz Meneses Ivan E, Cervantes Arriaga Amin, Rodríguez Violante Mayela.
Diagnostic utility of [11C]DTBZ Positron emission tomography in clinically uncertain parkinsonism
experience of a single tertiary center
Rev Invest Clin 2018; 70(6)  : 285-290

Resumen
 

Background: The use of single-photon emission computed tomography and positron emission tomography (PET) has proven to be helpful in differentiating Parkinson´s disease (PD) from other movement disorders with a sensitivity of up to 95%.

Objective: The objective of this study was to determine the accuracy of [11C]DTBZ PET imaging in patients with clinically uncertain parkinsonism from a tertiary referral center in Mexico City.

Materials and Methods: Patients who underwent [11C]DTBZ PET brain scan due to clinically uncertain parkinsonism where divided into two groups: PD or non-PD. A scan was considered positive when visual assessment revealed a decrease in [11C]DTBZ uptake typical for PD; a scan was considered negative when visual assessment showed no decrease in [11C]DTBZ uptake or showed a decrease in tracer uptake in a non-PD pattern. Sensitivity, specificity, and positive and negative predictive values were calculated using a 2 x 2 table, with a 95% confidence interval.

Results: A total of 39 patients were included in the study. 14 PET studies were deemed positive and 25 PET studies were deemed negative; 12 true positives and 23 true negatives were found. This yielded a sensitivity of 92.9% (95% CI, 66.1-99.8), specificity of 92% (95% CI, 74-99), PPV of 86.7% (95% CI, 63.1-96.1), and NPV of 95.8% (95% CI, 79.1-98.4).

Conclusions: The [11C]DTBZ PET has an excellent accuracy for differentiating idiopathic PD from other disorders.


Palabras clave: Positron emission tomography. [11C]DTBZ. Parkinsonism. Differential diagnosis.
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