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Miércoles 30 de septiembre 2020   BUSQUEDA
Alsaad  Ali A, Stancampiano  Fernando F, Palmer  William C, Henry  April M, Jackson  Jillian K, Heckman  Michael G, Diehl  Nancy N, Keaveny  Andrew P.
Serum Electrolyte Levels and Outcomes in Patients Hospitalized with Hepatic Encephalopathy
Ann Hepatol 2018; 17(5)  : 836-842


Introduction and aims. Serum electrolyte derangements are common in patients with decompensated cirrhosis hospitalized for hepatic encephalopathy. There are limited data describing the association between electrolyte levels and outcomes in hepatic encephalopathy. We assessed the association between initial serum electrolyte values and outcomes in patients with hepatic encephalopathy.

Material and methods. A total of 385 consecutive patients hospitalized with encephalopathy were included in the study. Baseline electrolyte levels (sodium, potassium, chloride, bicarbonate, calcium and phosphorus) were measured at the time of admission and assessed for association with outcomes, which included survival, admission to the intensive care unit, requirement for mechanical ventilation, and length of hospital stay. P-values 0.0083 were considered significant after adjustment for multiple testing.

Results. In unadjusted analysis, significant associations were identified regarding both bicarbonate and phosphorus (admission to intensive care unit), and calcium (mechanical ventilation); however these findings weakened and no longer approached statistical significance when adjusting for confounding variables. No other significant associations between serum electrolyte measurements and outcomes were observed.

Conclusions. Our findings suggest that in patients hospitalized with encephalopathy, serum electrolyte measurements are not strong predictors of patient outcome.

Palabras clave: Hepatic encephalopathy, serum electrolytes, mortality risk, hospitalization outcomes.
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