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TO THE EDITOR: Recently, Wunsch, et al. reported that hyponatremia, psychometric hepatic encephalopathy (HE) score, critical flicker frequency and severity of liver disease affect health-related quality-of-life (HRQOL) in patients with cirrhosis. In addition, Ahluwalia, et al. evaluated the contribution of hyponatremia to impairment HRQOL, cognitive dysfunction and brain magnetic resonance (MR) spectroscopy parameters in cirrhotic patients independently of HE. They showed that cirrhotic patients with hyponatremia had worse HRQOL despite better cognition and the poor HRQOL was associated with decreased myoinositol. Based on these observations, they concluded that hyponatremia worsens HRQOL due to changes in brain osmolarity in subjects with hyponatremia compared to those without it.

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2014-04-12   |   377 visitas   |   Evalua este artículo 0 valoraciones

Vol. 13 Núm.3. Mayo-Junio 2014 Pags. 407-408 Ann Hepatol 2014; 13(3)