Article commented Rockey DC, Vierling JM, Mantry P, Ghabril M, Brown Jr., RS, Alexeeva O, Zupanets IA, et al. For the HALT-HE Study Group.Randomized, doubleblind, controlled study of glycerol phenylbutyrate in hepatic encephalopathy. Hepatology 2014; 59: 1073-83. Comment Hepatic encephalopathy (HE) is a serious neuropsychiatric complication of both acute and chronic liver disease. Historically, the role of ammonia accumulation has dominated explanations of the pathogenesis of HE. However, evidence has emerged for a role of other concurrent factors such as inflammation, hyponatremia, neurosteroids, oxidative and nitrosative stress, manganese with cerebral edema.
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Vol. 13 Núm.3. Mayo-Junio 2014 Pags. 409-411 Ann Hepatol 2014; 13(3)