Dear Editor-in-Chief: Hepatitis-associated aplastic anemia (HAAA) is a distinct variant of acquired aplastic anemia, in which an acute attack of hepatitis leads to marrow failure and pancytopenia. Similar to other cases of acquired aplastic anemia (AA), HAAA results from an autoimmune attack directed against hematopoietic stem/ progenitor cells. AA and paroxysmal nocturnal hemoglobinuria (PNH) are closely related bone marrow failure disorders. We report the first case of severe HAAA-PNH associated with non-A-E Hepatitis virus infection that was treated with high dose cyclophosphamide therapy and then subsequent allogeneic bone marrow transplantation (BMT). A 22 Year old old female presented to the emergency room with 1 month history of generalized purpura and epistaxis.
2014-07-07 | 288 visitas | Evalua este artículo 0 valoraciones
Vol. 13 Núm.4. Julio-Agosto 2014 Pags. 466-467 Ann Hepatol 2014; 13(4)