Resumen

The effectiveness of Perioperative antibiotic prophylaxis (PAP) in reducing surgical site infections (SSIs) has been demonstrated. Its usefulness is recognized for clean-contaminated (CC) procedures and some clean surgeries (CS). Prophylactic antibiotics are used as intended to cover the most common germs in the surgical site; first- and second-generation cephalosporins are those that are most frequently employed. For optimal prophylaxis, an antibiotic with a targeted spectrum should be administered at sufficiently high concentrations in serum, tissue, and the surgical wound during the time that the incision is open and there is a risk of bacterial contamination. Infusion of the first dose of antimicrobials should begin within 60 min prior to the surgical incision and should be discontinued within 24 h after the end of surgery. Prolonged use of antibiotic prophylaxis leads to the emergence of bacterial resistance and high costs. The principles of antimicrobial prophylaxis in cancer surgery are the same as those described for general surgery; it is recommended to follow and comply with the standard criteria. In mastectomies and clean head and neck surgery, there are specific recommendations that differ from those for non-cancer surgery. In the case of very extensive surgeries, such as pelvic surgery or bone surgery with reconstruction, extension of antibiotics for 48?72 h should be considered.

Palabras clave: Antimicrobial prophylaxis in surgery surgical infection prevention cancer.

2014-11-07   |   263 visitas   |   Evalua este artículo 0 valoraciones

Vol. 63 Núm.6. Noviembre-Diciembre 2011 Pags. 630-640 Rev Invest Clin 2011; 63(6-ENGLISH)