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Article Commented: Binding of hepatitis B virus to its cellular receptor alters the expression profile of genes of bile acid metabolism. Oehler N, Volz T, Bhadra OD, Kah J, Allweiss L, Giersch K, Bierwolf J, Riecken K, Pollok JM, Lohse AW, Fehse B, Petersen J, Urban S, Lütgehetmann M, Heeren J, Dandri M. Hepatology 2014; 60(5): 1483-93. Comment: In the paper by Oehler, et al., the authors have investigated whether the interaction between HBV and the major carrier accounting for bile acid uptake by hepatocytes from sinusoidal blood, the Na+-taurocholate cotransporting polypeptide (NTCP), results in alterations in bile acid homeostasis and subsequently in an impairment in the hepatic metabolism of cholesterol and other lipids. To carry out this study, the authors have used HBV-infected and uninfected human liver chimeric mice.

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2014-12-22   |   436 visitas   |   Evalua este artículo 0 valoraciones

Vol. 14 Núm.1. Enero-Febrero 2015 Pags. 143-144 Ann Hepatol 2015; 14(1)