Article commented: Lee SM, Zhang Y, Tsuchiya H, Smalling R, Jetten AM, Wang L. Small heterodimer partner/neuronal PAS domain protein 2 axis regulates the oscillation of liver lipid metabolism. Hepatology 2015; 6: 497-505. Comment: Small heterodimer partner (SHP, NR0B2) interacts with orphan members of the nuclear receptor superfamily, including the constitutive androstane receptor, retinoid receptors, thyroid hormone receptor, and orphan receptor MB67. The SHP ability to bind directly to a variety of nuclear receptors is crucial for its physiological function as a transcriptional inhibitor of gene expression. SHP binds to the ligand-dependent transactivation domain AF-2 through two functional LXXLL-related motifs which are located in the putative N-terminal helix 1 of the ligand-binding domain LBD and in the helix of the C-terminal region. SHP gene is expressed and detected in a variety of tissues in mice and human. For example, in some strain of mice (12931/SvJ and C57/BL6) as well as in humans SHP is predominantly expressed in the gallbladder and liver.
2015-02-04 | 357 visitas | Evalua este artículo 0 valoraciones
Vol. 14 Núm.2. Marzo-Abril 2015 Pags. 286-287 Ann Hepatol 2015; 14(2)