Association between high serum estradiol levels and delirium among hospitalized elderly women

Autores: Ávila Funes José Alberto, Ledesma Heyer Juan Pablo, Navarrete Reyes Ana Patricia, Chavira Ramírez Roberto, Boeck Quirasco Lourdes, Aguilar Navarro Sara


Background: Delirium is a common and serious disorder among hospitalized elderly individuals. We investigated the association between serum estradiol levels and incident delirium. Methods: Longitudinal study of 141 women ≥ 70 years old admitted to a tertiary care hospital in Mexico City. All participants underwent a comprehensive geriatric assessment. Blood samples for cortisol and estradiol determination were obtained at hospital admission. Incident delirium was investigated until participants were discharged. Multivariate models were run to test the independent association between estradiol levels and incident delirium. Results: Twenty-three (16.3%) participants developed delirium. Estradiol levels were higher among women with incident delirium compared with non affected women. Multivariate logistic regression analysis showed that serum estradiol levels were associated with incident delirium even after adjusting for multiple confounding covariates, including cortisol levels (OR: 1.93; 95% CI: 1.28-2.92). Conclusions: Elderly women with high serum estradiol levels at hospital admission had an increased risk for incident delirium. Serum estradiol may be a biomarker for increased risk of delirium.

Palabras clave: Delirium estradiol elderly hospitalization.

2016-04-20   |   137 visitas   |   Evalua este artículo 0 valoraciones

Vol. 67 Núm.1. Enero-Febrero 2015 Pags. 20-24 Rev Invest Clin 2015; 67(1 ENGLISH)