Resumen

Background and aims: Cytokeratin19 positive (CK19⁺) hepatocellular carcinoma (HCC) is thought to derive from liver progenitor cells (LPC). However, whether peritumoralductular reaction (DR) differs between CK19⁺ and CK19 negative (CK19^-) HCC patients remains unclear. Material and methods: One hundred and twenty HBV-related HCC patients were enrolled in this study. Clinicopathological variables were collected, and immunohistochemistry staining for CK19, proliferating cell nuclear antigen (PCNA), interleukin-6 (IL-6) and -catenin were performed in tumor and peritumor liver tissues. Results: CK19⁺ HCC patients had higher grade of peritumoral DR and proportion of proliferative DR than the CK19- group. The mean number or the proportion of cytoplasmic β-catenin⁺ DR was higher in the CK19⁺ group than in the CK19^- group. Furthermore, there were more patients with nuclear β-catenin⁺ peritumoral DR in the CK19⁺ group as compared to the CK19^- group. Conclusion: Peritumoral DR was more abundant and proliferative in CK19⁺ HCC patients, with higher level of nuclear translocation of β-catenin. However, it is unclear whether peritumoral DR is the cause or result of poor prognosis in these patients.

Palabras clave: Liver cancer liver progenitor cells β-catenin.

2016-06-24   |   296 visitas   |   Evalua este artículo 0 valoraciones

Vol. 15 Núm.3. Mayo-Junio 2016 Pags. 386-393 Ann Hepatol 2016; 15(3)