Resumen

Background: Resistance to antifungal drugs, especially towards triazoles, is commonly referred to by clinicians, but data on its prevalence in developing countries is limited. Methodology: To determine the prevalence of triazole-resistance amongst pathogenic yeasts and moulds, we assessed the in vitro susceptibility of 250 isolates from hospitalized patients at five Mexican cities towards amphotericin B, fluconazole and voriconazole, by E-test. Results: All yeasts were susceptible to voriconazole, according to E-test interpretive criteria (MIC ≤ 1 ìg/mL), and all filamentous or dimorphic fungi also had voriconazole MIC ≤ 1 ìg/mL, except for one isolate each of Mucor sp. and Acremonium sp. Candida krusei and one isolate of C. glabrata were resistant to fluconazole, a drug that had MIC ≥ 192 ìg/mL for filamentous fungi. Although no breakpoints for amphotericin B are available, all three C. krusei, 2/25 C. glabrata, 3/22 C. parapsilosis and 1/108 C. albicans had MIC ≥ 2 ìg/mL. Conclusion: The In vitro, voriconazole is active against yeasts and moulds commonly causing severe mycoses in Mexico.

Palabras clave: Candida spp. moulds in vitro susceptibility azoles amphotericin B.

2009-12-14   |   527 visitas   |   Evalua este artículo 0 valoraciones

Vol. 3 Núm.5. Junio 2009 Pags. 398-401. J Infect Developing Countries 2009; 3(5)