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In the last issue of Annals of Hepatology, Fisher and colleagues, from the liver transplant program of the Virginia Commonwealth University, reported their prospective decade long experience with adult live donor liver transplantation (ALDLT) compared to their adult deceased donor liver transplant (ADDLT) outcomes. The cumulative number of transplants performed in each of the study groups was impressive (n = 107 ALDLT, n = 465 ADDLT), the outcomes, however, were even more impressive and add to the growing collection of papers in the medical/surgical literature suggesting that ALDLT is a very feasible venture when performed at experienced centres. Fisher et al reported that overall graft and patient survival between ALDLT and ADDLT were similar (1, 3 and 5 year patient survival: 82.7%, 76.9% and 75.5% ALDLT vs. 86.1%, 77.1% and 72.0% ADDLT, p value not significant) and the incidence of acute graft rejection was significantly less in the ALDLT group vs. ADDLT (12.7% vs. 21.7%, p = 0.05). Although the larger NIH ALDLT vs. ADDLT study, of which Fisher et al’s group participated, reported no significant difference in acute graft rejection between the two groups (in contrast to Fisher, et al.) it is apparent that acute rejection is not a problem in ALDLT. A noteworthy finding was that with hepatitis C (HCV), which constituted almost half of the transplants in both groups, histologic graft recurrence at one year was not significantly different between groups.

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2010-05-11   |   637 visitas   |   Evalua este artículo 0 valoraciones

Vol. 9 Núm.1. Enero-Marzo 2010 Pags. 89-90 Ann Hepatol 2010; 9(1)