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To the Editor, The relation between HBV and glomerulonephritis including membranous and mesengio-proliferative glomerulonephritis has been well documented. However, only six cases of HBV associated focal segmental glomerulosclerosis (FSGS) were reported previously. Reduction of HBV DNA titers is important for remission of HBV-associated glomerulopathies. We herein represent a case of HBV-associated FSGS who relapsed under lamivudine therapy and improved with tenofovir treatment. We reviewed the pertinent literature regarding HBV-associated FSGS. A 26 year-old man was admitted to our clinic with severe edema. He had a history of HBV infection for eight years. During follow up for HBV, his liver enzymes were within normal limits and HBV DNA was lower than 2,000 IU/mL hence did not need any treatment. Physical examination revealed 4 + pretibial edema. In his laboratory examination; BUN: 26 mg/dL, serum creatinine: 0.8 mg/dL, AST: 20 IU/L, ALT: 46 IU/L, Hbe Ag negative, anti-Hbe positive, HBV DNA: 1254 IU/mL, serum albumin: 2.5 g/dL and total protein excretion was 14.2 g/day in 24 h urine samples.

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2011-06-13   |   751 visitas   |   Evalua este artículo 0 valoraciones

Vol. 10 Núm.3. Julio-Septiembre 2011 Pags. 372-373 Ann Hepatol 2011; 10(3)