Albumin dialysis with molecular adsorbent recirculating system (MARS) for the treatment of hepatic encephalopathy in liver failure

Autores: Kobashi Margáin Ramón Arturo, Gavilanes Espinar Juan G, Gutierrez Grobe Ylse, Gutiérrez Jiménez Ángel A, Chavez Tapia Norberto Carlos, Ponciano Rodríguez Guadalupe, Uribe Esquivel Misael, Méndez Sánchez Nahum


Acute, acute-on-chronic and chronic liver diseases are major health issues worldwide, and most cases end with the need for liver transplantation. Up to 90% of the patients die waiting for an organ to be transplanted. Hepatic encephalopathy is a common neuropsychiatric syndrome that usually accompanies liver failure and impacts greatly on the quality of life. The molecular adsorbent recirculating system (MARS) is a recently developed form of artificial liver support that functions on a base of albumin dialysis. It facilitates the dialysis of albumin-bound and water-soluble toxins, allowing the patient to survive and even improving some clinical features of liver failure. The following manuscript reviews the technical features of MARS operation and some of the clinical trials that analyze the efficacy of the system in the therapy of liver diseases.

Palabras clave: Molecular adsorbent recirculating system hepatic encephalopathy acute liver failure acute-on-chronic

2011-08-10   |   352 visitas   |   Evalua este artículo 0 valoraciones

Vol. 10 Núm.2. Julio 2011 Pags. 66-69 Ann Hepatol 2011; 10(Supl. 2)