Acetylcholinesterase and butyrylcholinesterase as markers of low-grade systemic inflammation

Autor: Das Undurti N.

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Low-grade systemic inflammation plays a significant role in the pathogenesis of insulin resistance, type 2 diabetes mellitus, hypertension, hyperlipidemias, Alzheimer’s disease, proliferative diabetic retinopathy; age-related macular degeneration, minimal change nephropathy and various rheumatological conditions. Hence, development of reliable, unique and robust markers is essential. In this context, I noted that plasma and/or tissue levels of acetylcholinesterase and butyrylcholinesterase activities could form reliable indices to detect and diagnose the existence of low-grade systemic inflammation in all the above-mentioned conditions. The work of Lampón, et al. published in the present issue wherein they observed a significant positive correlation between butyrylcholinesterase (BChE) and hs-CRP though, for hsCRP concentrations > 3 mg/L the correlation between these variables (BChE and hs-CRP) was found to be significantly negative (p < 0.001), as in patients with acute inflammation (hsCRP > 10 mg/L) is in support of this contention. It is interesting that BChE activity was negatively correlated with hs-CRP when the latter levels are more than 3 mg/L. The close positive correlation seen between BChE and plasma albumin concentrations not only suggests that hepatic tissue produces these two molecules in a coupled fashion but also implies that when the albumin synthesis is interfered with BChE may not a reliable marker of inflammation.

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2012-04-19   |   660 visitas   |   Evalua este artículo 0 valoraciones

Vol. 11 Núm.3. Mayo-Junio 2012 Pags. 409-411 Ann Hepatol 2012; 11(3)