Does the persistently normal aminotransferase levels in hepatitis C still have relevance?

Autores: Méndez Navarro Jorge, Dehesa Violante Margarita


Dear Editor: About one third of patients with chronic hepatitis C (HCV) have normal levels of aminotransferases (ALT). Most of these patients have mild disease with lower histological fibrosis, although some may progress to advanced fibrosis and cirrhosis. ALT’s are still the more accessible and inexpensive tests, but less sensitive, to determine the activity of liver disease. A single measurement provides limited information and there is a weak association between elevation and severity of histopathological findings. Although an undetectable viral load (HCV RNA) is the key indicator of response to antiviral therapy, biochemical resolution with normalization of ALT for many authors is an important indicator of successful response.

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2012-04-19   |   593 visitas   |   Evalua este artículo 0 valoraciones

Vol. 11 Núm.3. Mayo-Junio 2012 Pags. 412-414 Ann Hepatol 2012; 11(3)