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Comments After the first report of an association of viral infection and atherosclerosis in 1970, several studies have suggested that there is a link between arteriosclerotic disease and persistent infection or seropositivity of certain micro-organisms, such as Chlamydia pneumoniae, cytomegalovirus, Helicobacter pylori, and herpes simplex virus. The pathogenetic mechanisms may vary and are still poorly understood. Evidence demonstrate that hepatitis C virus, alone or in association with other viral infections, is involved in the development and progression of carotid atherosclerosis. Given their association with inflammation which is now seen as a key event in the atherosclerotic process. Infectious pathogens induce macrophage foam cell formation and induce activation of the immune response and potentiate the immune inflammatory reaction underlying atherosclerosis. A retrospective analysis undertook a systematic review of the literature to study the association between HCV and carotid atherosclerotic plaques. A total of 18 studies in the English language were identified.

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2012-06-14   |   901 visitas   |   Evalua este artículo 0 valoraciones

Vol. 11 Núm.4. Julio-Agosto 2012 Pags. 574-575 Ann Hepatol 2012; 11(4)