Hormone replacement therapy and dry eye in post menopausal women:

study in a tertiary centre in Malaysia 

Autores: Din Norshamsiah M, Sa’aid Siti HB, Shen Lam C, Shu Yap S, Rahman Marina BA, Azmi Aini BM, Thing Chang S, et al


Background: Menopause involves decrease in the body estrogen level. There are many disorders associated with estrogen deficiency state. Postmenopausal women frequently report dry eye symptoms due to the decrease in the level of circulating estrogen hormone. Hormone replacement therapy (HRT) is given to alleviate some of the menopausal effects. This study aimed to compare the tear production between postmenopausal women treated with or without HRT. Methods: This cross-sectional study was performed on 140 participants attending various clinics in Universiti Kebangsaan Malaysia Medical Centre (UKMMC) namely the obstetric and gynecology, Surgery, Orthopedic and Otorhinolaryngology clinics over a period of 3 months. The subjects were either with or without HRT. Schirmer’s Test strip was used to measure the tear quantity. Dry eye was defined when the length of the moistened area on the strip is less than 5 mm. Results: The results showed significant difference in tear quantity in postmenopausal women treated with or without HRT (p = 0.003). No correlation was observed between tear quantity and duration of HRT consumption, (p = 0.217).No significant correlation was also found between the tear quantity and duration of menopause (p = 0.150). Conclusions: Our results suggested that HRT helps in improving tear production in postmenopausal women regardless of the duration of HRT consumption or menopause However, duration of HRT consumption or menopause exert no significant effect on the tear quantity.

Palabras clave: Postmenopausal women hormone replacement therapy dry eye syndrome.

2013-05-08   |   1,264 visitas   |   Evalua este artículo 0 valoraciones

Vol. 1 Núm.1. Enero 2013 Pags. 12-15 Int J Med Students 2013; 1(1)