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Article commented Piano S, Rosi S, Maresio G, Fasolato S, Cavallin M, Romano A, Morando F, et al. Evaluation of the Acute Kidney Injury Network criteria in hospitalized patients with cirrhosis and ascites. J Hepatol 2013; 59: 482-9. Comment Renal failure in cirrhosis has been arbitrarily defined as an increase in serum creatinine (SCr) over 1.5 mg/dL which corresponds to a glomerular filtration rate (GFR) of approximately 30 mL/min. This definition (conventional criteria), proposed in 1996 by the International Ascites Club for has been widely accepted one among the hepatology community. Although hepatologists have accepted this definition, the nephrology community has been more skeptical mainly because SCr is a suboptimal marker for renal function because it may overestimate GFR, mainly due to decreased creatinine production or reduced muscle mass. Furthermore, a SCr level below 1.5 mg/dL does not necessarily exclude renal dysfunction.

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2014-03-01   |   320 visitas   |   Evalua este artículo 0 valoraciones

Vol. 12 Núm.6. Noviembre-Diciembre 2013 Pags. 984-985 Ann Hepatol 2013; 12(6)